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What does congenital adrenal hyperplasia do? Congenital adrenal hyperplasia is an inherited condition caused by mutations in genes that code for enzymes involved in making steroid hormones in the adrenal glands. The most common enzyme defect, 21-hydroxylase deficiency, leads to excess amounts of male hormones being produced by the adrenal glands.
Is CAH hereditary? CAH is passed along in an inheritance pattern called autosomal recessive. Children who have the condition have two parents who either have CAH themselves or who are both carriers of the genetic mutation that causes the condition.
What is mild adrenal hyperplasia? Congenital adrenal hyperplasia, also called CAH, is a group of genetic disorders in which the two adrenal glands do not work properly. CAH can be severe (classic) and diagnosed in the newborn, but it can also be mild (nonclassic) and not show up until later childhood, adolescence or adulthood.
How often are adrenal tumors cancerous? Malignant adrenal tumors, which are cancerous, are diagnosed in only 300 to 500 people each year, and they are usually adrenal cortical carcinomas.
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